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Project abstract for group vanness
Genomic Analysis of Drug Response in Myeloma
This project involves defining genomic variations that contribute to drug sensitivity and resistance in the plasma cell malignancy, multiple myeloma. Gene expression and genomic variations are being analyzed in attempts to develop biomarker predictors of response and to better understand mechanisms leading to changes in drug sensitivity of cancer cells. MSI is used for data management and for analytical tools like Ingenuity systems to develop connectivity maps of common pathways involved.