Project abstract for group wagnercr

Development of Antiviral and Anticancer Therapeutics

The goal of this laboratory is to apply the principles of chemical biology and medicinal chemistry to the design of new chemical- and cell-based therapies by:

  • Applying chemical induced dimerization to guide the self-assembly of protein nanorings that can be used for drug delivery, tumor imaging and the targeting of immune and stem cells for tumor targeting or tissue regeneration.
  • Designing therapeutic nucleotide prodrugs that can be targeted too and activated by diseased tissues.
  • Uncovering the natural function of Hint proteins and applying our knowledge to the design of anticancer, antiviral drugs and new pain medications.

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