Research Spotlights Digest

Tim Mulcahy speaking VP for Research Tim Mulcahy Retirement


MSI honored the retirement of the University of Minnesota Vice President for Research (VPR), Tim Mulcahy, with a special event on October 29, 2012. VP Mulcahy will be retiring from the University on December 31.


MSI came under the Office of the VPR in July 2008, and VP Mulcahy has been a staunch supporter of MSI’s mission during the past four years. He was instrumental...Read more

structure model of HIV integrase HIV/AIDS Drug Development


Scientists are now using computers to help discover new drugs. Researchers at the University’s Center for Drug Design are in the forefront of these efforts. Professor Yuk Sham and his research group are studying the molecular recognition process of how molecules selectively associate with one another....Read more

Computer Simulations of Protein Kinase A

Protein kinase A (PKA) is involved in many cellular events and its activity can be tweaked and compartmentalized through mirystoylation of its N-terminus. (Mirystoylation is a type of protein modification that plays a role in directing and anchoring proteins to membranes and, thus, is involved with cellular regulation, signal transduction, and apoptosis.) 

Research Associate Dr....Read more

High-Throughput Data Transfer for Astrophysics Simulations


MSI, with the support of the University of Minnesota’s NTS (Network and Telecommunication Services), has recently deployed a system to take advantage of the ten-gigabit network known as the Northern Lights GigaPoP network. With this system in place, MSI was able to help Peter J. Mendygral, a post-doctoral member of MSI principal...Read more

Computational Modeling of Endovascular Deep Brain Simulation


Deep brain stimulation (DBS) is a surgical therapy used to treat many neurological disorders that are refractory to medication. Patients with severe Parkinson’s disease, dystonia, essential tremor, obsessive-compulsive disorder, and depression have all benefited from DBS. The therapy involves implanting small electrodes in brain regions that exhibit pathological activity, and then...Read more

air-flow streamlines around tower Modeling and Analysis for New Wind Technology


Minnesota Supercomputing Institute (MSI) Provides Modeling and Analysis Support for Development of INVELOX, A Wind-Generated Energy Technology Developed by SheerWind, Inc.

SheerWind, Inc., a Minnesota-based company, has been developing novel approaches for generating electric power from the wind. In the fall of 2011,...Read more

MSI Supporting DOE Grants in Computational Chemistry


MSI is proud to spotlight some of our researchers in a new series of articles that are aimed both at highlighting their research and illustrating how MSI facilitates it. Christopher Cramer’s group uses supercomputing resources to push the limits of present-day computational chemistry tools in order to examine...Read more

Finite Element Exterior Calculus With FEniCS


Researchers in higher mathematics have long used supercomputers to handle the huge numbers of calculations necessary for their work. Professor Doug Arnold (Mathematics; MSI Fellow) is using Itasca to solve problems with various aspects of finite-element methods...Read more

molecule vizualizations A Searchable Database of Macromolecular Conformation


The research group of Professor Barry Finzel (Medicinal Chemistry) is developing a centralized database and associated application suite that support searching for complex substructures in macromolecules, storing and sharing user-provided macromolecular data, and presenting search results. Post-Doctoral...Read more

simulation of flow breakup Modeling Turbulent Multiphase Flows


Aerosol sprays are a major area of study because of the many industrial, agricultural, and pharmaceutical (among others) applications of such work. The research group of Sean Garrick (Mechanical Engineering; MSI Fellow) in the Computational Transport Phenomena Laboratory has a long history in the direct...Read more

VR simulation of Thersilion on Powerwall Ancient Greek Rhetoric in Immersive Virtual Reality


The acoustics of ancient Greek theaters and auditoriums have long fascinated archeologists and historians. Researchers using the LCSE-MSI Visualization Laboratory (LMVL) are creating virtual-reality simulations of ancient structures to determine how variables of architecture design affected the sound, sight lines, and behaviors of speakers and listeners in those spaces. This long-term...Read more

Notre Dame images Sparse Coding Algorithm for Image Searching


Nearest Neighbors (NN) is a fundamental operation in many areas of scientific computing, including computer vision, machine learning, robotics, and data mining. It is the backbone of applications people use every day, such as Google Images. Images tend to be high-dimensional, and as the dimensionality of the data increases, the NN task becomes computationally more difficult. This is...Read more