Research Spotlights Digest

Targeting Drugs to Tumors

One of the most promising methods of treating cancer is called “tumor-homing” or “targeted drug” therapy. In this method, a cancer drug is linked to a kind of peptide called a “tumor-homing” peptide – the tumor-homing peptide recognizes a specific receptor that appears on tumors, thereby guiding the drug directly to the tumor. One such receptor...Read more

A Novel Two-Dimensional Copper-Silicon Material

Image description: Left: Top and side views of a section of a two-dimensional Cu2Si monolayer. Cu atoms copper colored, Si atoms grey. Right: Bonding structure of the Cu2Si monolayer. (a-c) Individual 4c-2e σ...Read more

Mesabi, MSI's New Supercomputer

Mesabi, the Minnesota Supercomputing Institute’s newest supercomputer, was formally dedicated on April 23, 2015. Mesabi is the latest in a long line of supercomputers that have been serving the University of Minnesota research community for 30 years.

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The Fungal Microbiome in Infants

Research has shown that the human microbiome - the community of microorganisms that inhabit our bodies - may have health implications. It’s possible, for example, that a certain mixture of these microorganisms may cause certain diseases....Read more

graphics from Research Exhibition winning posters Mesabi Dedication and 2015 Research Exhibition


On Thursday, April 23, MSI held the sixth annual MSI Research Exhibition and dedicated our newest supercomputer, Mesabi. Mesabi is an HP distributed...Read more

Understanding the Effects of Dislocations on Thermal Properties of Materials

Materials whose atoms form a crystal structure - the atoms are organized in a symmetric spatial arrangement - are useful for various applications, such as electronics. During the crystal growth process, dislocations can form. One type is called a “screw dislocation,” which can be seen in the image above. Defects in a crystal will affect its...Read more

New Data Storage Option for MSI Researchers

In the fall of 2014, MSI added a Ceph object storage system as an option for second-tier storage for MSI users. Many MSI researchers are in disciplines that use huge amounts of data, such as informatics, genomics, and astrophysics. Often, much of this data does not need to be stored on a machine with high-speed access. This is where a good...Read more

Investigating the Medicinal Properties of Kava ('awa)

For centuries, Pacific Islanders have used the kava (Piper methysticum G. Forster) plant to make water-based drinks for medicinal and ceremonial use. Kava, prepared with water, is also traditionally used as a daily drinking beverage at the...Read more

Effects of Alternative Fuels on Air Quality

Concern about the level of greenhouse gases in the atmosphere and the resulting impacts on global climate has led many to look for alternative technologies. Since automobiles have become a major source of greenhouse gases, scientists and engineers have been working to develop cars that run on alternative fuels. There are a number of options,...Read more

molecule diagrams Using Computational Chemistry to Study Dusty Plasmas

Plasmas are used in industrial processes in several important high-technology industries, such as the semiconductor industry. One application is the use of chemically reactive plasmas to deposit extremely thin films on other materials. So-called “dusty” plasmas contain particulates; these plasmas are of great interest to industry, as...Read more

Creating Compounds to Treat Disease

Sirtuins are a group of seven compounds (SIRT1 - SIRT7) that are involved in a wide range of biological functions. Because of their role in gene regulation, researchers believe that sirtuin inhibitors may be useful as treatments for diseases. For example, drug designers believe that SIRT2 inhibition could be a useful treatment for Parkinson’s...Read more

Supernovae of Early Supermassive Stars

Most galaxies that we have observed contain at their centers a supermassive black hole. While scientists don’t know how these black holes were formed, they have surmised that they could be the remnants of supermassive stars that, at the end of their lives, collapsed to create the black holes. Researchers use computer modeling to study this...Read more

images of papyri Translational Informatics

Application of Informatics to Transcription of Ancient Papyri 

While computers can do many things, there are still a few areas in which humans excel such as the discriminatory power of the eye and the natural human ability to quickly classify objects. The visual ability of recognizing patterns is at the core of the...Read more

Blind Cavefish Genome

photo credit: Bethany A. Stahl

Animals that move from surface habitats into caves exhibit evolutionally related changes in their new environments. Perhaps the most dramatic is eye loss, but there are also other changes, such as skin pigmentation and sleeping patterns. Researchers believe that studying how these changes occur and the genes...Read more

Using Proteomics Methods to Diagnose Oral Cancer

Oral cancer is a virulent form of the disease, with a nearly 50 percent mortality rate. Early diagnosis is one of the keys to successful treatment; patients whose cancer is found and treated early have a much better survival rate. Unfortunately, the current method of diagnosing the disease, which involves excision and biopsy of tissue, is both...Read more