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Brain Imaging With Serial Optical Coherence Scanning

Abstract: 
<h3 class="red">Brain Imaging With Serial Optical Coherence Scanning</h3><p>These researchers are developing an optical imaging technique called serial optical coherence scanning (SOCS) that will be used for studying brain anatomy. The research will enable a comprehensive three-dimensional reconstruction of the brain and cerebellum, and support quantitative assessments on white matter content and organization.</p><p>Return to this PI&#39;s <a href="https://www.msi.umn.edu/pi/3bc5d66913873caeb297d60cf2dfa458/10510">main page</a>.</p>
Group name: 
akkint

Design and Conformational Analysis of Synthetic Anion Receptors

Abstract: 
<h4>Design and Conformational Analysis of Synthetic Anion Receptors</h4><div class="node-column-original" style="font-size: 14px; background-color: rgb(255, 255, 255); color: rgb(51, 51, 51);"><div class="view view-access-requests view-id-access_requests view-display-id-by_group_name view-dom-id-34fd08efa2aebd56f5fcb556d98d74b9" style="font-size: 14px;"><div class="view-content" style="font-size: 14px;"><div class="views-row views-row-1" style="font-size: 14px;"><p class="views-field views-field-abstract" style="font-size: 14px;"><span class="field-content" style="font-size: 14px;">The main focus of this lab is in the area of supramolecular chemistry of anions &ndash; in particular, chloride ions. The researchers use Gaussian at MSI to conduct: DFT studies to optimize receptor design for various anions differing in shape and size; and DFT studies to evaluate conformations of different synthetic receptors both in the anion bound and free state. They also hope to conduct TD-DFT calculations in the future to investigate the origin of absorption and emission characteristics (if any) of the synthetic anion receptors to explore their potential utility as sensors.</span></p></div></div></div></div><p>&nbsp;</p>
Group name: 
muthyal0

Computational Chemistry

Abstract: 
<div class="node-column-original" style="font-size: 14px; background-color: rgb(255, 255, 255); color: rgb(51, 51, 51);"><div class="view view-access-requests view-id-access_requests view-display-id-by_group_name view-dom-id-1b61323b188b3c0fe150f2683573cccc" style="font-size: 14px;"><div class="view-content" style="font-size: 14px;"><div class="views-row views-row-1" style="font-size: 14px;"><h4 class="views-field views-field-abstract" style="font-size: 14px;">Computational Chemistry</h4><p class="views-field views-field-abstract" style="font-size: 14px;"><span class="field-content" style="font-size: 14px;">This group is using MSI resources to model chemical systems of interest in their research group. These may be conformational studies of molecules, electrochemical, or transition metal species. The researchers seek to gain insights into mechanism and physical properties.</span></p><p class="views-field views-field-abstract" style="font-size: 14px;"><span style="font-size: 14px; line-height: 1.5;">A bibliography of this group&rsquo;s publications is attached.</span></p><p class="views-field views-field-abstract" style="font-size: 14px;">Return to this PI&#39;s <a href="https://www.msi.umn.edu/pi/8341ed7c9e80776ff4842de5b50475eb/17273">main page</a>.</p><p class="views-field views-field-abstract" style="font-size: 14px;">&nbsp;</p></div></div></div></div><p>&nbsp;</p>
Group name: 
douglasc

Development and Application of Computational Models for Purposes of Investigating Phenomena of Chemical, Biological, and Environmental Interest

Abstract: 
<h3 class="red">Development and Application of Computational Models for Purposes of Investigating Phenomena of Chemical, Biological, and Environmental Interest</h3><p>These researchers develop, code, and apply novel and/or established classical and quantum mechanical methodologies to model chemical structures, properties, and reactivities. Current areas of focus include:</p><ul><li>Modeling the factors that lead to improved performance of water-splitting catalysts in dye-sensitized solar cells</li><li>Rationalizing structure, reactivity, and experimental isotope effects in metalloenzyme systems and small-molecule models that activate molecular oxygen</li><li>Elucidating the factors controlling the thermochemistry of renewable polymer polymerization catalysts</li><li>Characterizing the dynamics of charge transfer in molecular wires and at complex interfaces</li><li>Modeling the use of metal-organic frameworks to serve as supports for catalysis of chemical transformations</li><li>Modeling detoxification mechanisms for chemical weapons agents and simulants</li><li>Designing catalysts for the capture and transformation of the greenhouse gas carbon dioxide</li><li>Including condensed-phase effects in quantum chemical calculations, particularly as it influences solvatochromism and redox properties</li></ul><p>Research Spotlights about this group&#39;s work appeared on the MSI website in <a href="https://www.msi.umn.edu/content/new-metal-organic-framework-catalysis">December 2015</a> and <a href="https://www.msi.umn.edu/content/using-computational-chemistry-solve-energy-challenges">May 2014</a>.</p><p>Return to this PI&rsquo;s <a href="https://www.msi.umn.edu/pi/a9f31cc2394351c23119ae4ef5da31d0/11700">main page</a>.</p>
Group name: 
cramercj

Biological Mass Spectrometry and Bioinformatics

Abstract: 
<h3 class="red">Biological Mass Spectrometry and Bioinformatics</h3><p>Work in the Griffin group involves the development and application of mass spectrometry-based tools to study proteins and proteomes. The goal of this work is to provide the necessary tools to enable the system-wide characterization of proteins expressed within a cell, tissue, biological fluid or organism, in order to better understand basic mechanisms of biological function and disease. These tools must be capable of measuring the many properties of proteins that collectively determine their function. These properties include protein abundance, sub-cellular localization, post-translational modifications, associations in non-covalent complexes and biochemical activity. Mass spectrometry provides a highly powerful tool that can aid in measuring these various protein properties, in a high-throughput manner. The development and application of these tools is highly interdisciplinary in nature, integrating front-end molecular biology and biochemical methods, protein and peptide chemistry, analytical separations, instrumental analysis, and back-end computation and bioinformatics for data analysis and biological interpretation.</p><p>The group works heavily with MSI, including an ongoing project called Galaxy-P, in which the Galaxy platform is being extended for proteomic and metabolomic data analysis applications. As part of this project, the group works with biologist collaborators from around the world to analyze data and provide insights into biological problems.</p><p>This PI&rsquo;s research was featured in MSI Research Spotlights in <a href="https://www.msi.umn.edu/content/using-proteomics-methods-diagnose-oral-cancer">October 2014</a> and <a href="https://www.msi.umn.edu/content/expanding-galaxy-platform">November 2015</a>.</p><p>Return to this PI&rsquo;s <a href="https://www.msi.umn.edu/pi/7dc3ead7f6ba21a3b94053a765a95da0/1006">main page</a>.</p><p>&nbsp;</p>
Group name: 
griffint

Investigation of mantle structure beneath subducting slabs

Abstract: 
<p><strong>Investigation of Mantle Structure Beneath Subducting Slabs</strong></p> <p>These researchers are investigating mantle structure beneath subducting former oceanic lithosphere. This region is of interest because of the profound differences in mantle water content compared with the &quot;wet&quot; mantle above the slab. Differences in how the cold slab affects mineralogical phase transitions between the dry sub-slab and wet supra-slab regions offers unique insight into the role water plays in mantle circulation and how abundant it is. This work requires detailed synthetic seismogram calculations in three dimensions and computation of the seismic structure expected with 3D mantle circulation.</p> <body id="cke_pastebin" style="position: absolute; top: 38px; width: 1px; height: 1px; overflow-x: hidden; overflow-y: hidden; left: -1000px; "> </body>
Group name: 
revenaug

Investigation of Pancreatic Cyst Fluid by Mass Spectrometry

Abstract: 
<h3 class="red">Investigation of Pancreatic Cyst Fluid by Mass Spectrometry</h3><p>This group&#39;s initial investigations into the protein content of pancreatic cyst fluid involved testing of unmodified fluid samples by MALDI (matrix assisted laser desorption ionization) mass spectrometry. This approach resulted in demonstration of hundreds of proteins. A variety of data analysis methods were employed, including pattern matching software and mathematical alignment programs available through MSI. This work is continuing in 2016.</p><p>Return to this PI&#39;s <a href="https://www.msi.umn.edu/pi/f80e6fa9fc55f02b7880f2ac2e8458b1/10148">main page</a>.</p>
Group name: 
streitzj

Swine Influenza A Virus Diversity and Evolution

Abstract: 
<h3 class="red">Swine Influenza A Virus Diversity and Evolution</h3><p>This research focuses on the molecular diversity and evolution of swine influenza A virus. The researchers use complete genome amplification and next-generation sequencing technologies to study the diversity and evolution of the virus under experimental and field conditions.</p><p>A Research Spotlight about this PI&#39;s work appeared in <a href="/content/determining-influenza-virus-infections-subpopulations-pigs">June 2016</a>.</p><p>Return to this PI&#39;s <a href="https://www.msi.umn.edu/pi/69769e60731cdac2738f87e9a6c50637/10317">main page</a>.</p>
Group name: 
torremor

Albinism Database

Abstract: 
<h3 class="red">Albinism Database</h3><p>The albinism database is a database of mutations within the genes associated with albinism. This database is used by researchers, clinicians, genetic counselors, and individuals who work in medical diagnostic laboratories. MSI web services provide a forwarding page for the database.</p><p>A Research Spotlight about this PI&#39;s work appeared in&nbsp;<a href="https://www.msi.umn.edu/content/finding-genetic-markers-transplant-rejection">February 2016</a>.</p><p>Return to this PI&rsquo;s <a href="https://www.msi.umn.edu/pi/8a95b00a546863750484811397feac23/30972">main page</a>.</p>
Group name: 
oettingw

Dynein Motors and Flagellar Motility

Abstract: 
<h3 class="red">Dynein Motors and Flagellar Motility</h3><p>These researchers study genes involved in the assembly, motility, and signaling of cilia and flagella. Cilia and flagella are required for sperm motility, the determination of the left-right body axis during development, the clearance of the respiratory tract, and signaling in a wide variety of tissues. Defects in the genes controlling cilia and flagella lead to a broad spectrum of human diseases known as ciliopathies.</p><p>This research was featured in an <a href="https://www.msi.umn.edu/content/seeking-causes-ciliary-dyskinesia">MSI Research Spotlight</a> in March 2014.</p><p>Return to this PI&#39;s <a href="https://www.msi.umn.edu/pi/3f3bdc0a0cbaa17eea8b05e6c5f52e48/46537">main page</a>.</p>
Group name: 
porterme

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