My expertise could be pinpointed into the following categories:
1. Good understanding on complex model systems: Hematopoieses system (human and mouse cell line) and human pathogen (bacteria – Bordetellae)
2. Proficient in Comparative Genomics analysis: Genome manipulation, including assembly, annotation and alignment; Sequence level analysis, including binding site motif discovery, quantifying conservation, repeats identification; Training models using real-world data
3. Proficient in Next-Generation Sequencing technologies: short reads mapping, assembling and peak calling
4. Programming Skills: Python, R (statistical) and C, excellence in Galaxy platform
Besides the above dry lab expertise, I am also familiar with some of the traditional wet lab technologies, such as PCR, transient transfection and stable transfection assays, linkage mapping, positional cloning and sequencing.
As a brief summary of my education and previous experience, I graduated from the University of Science and Technology of China (2002) and pursued a PhD degree at Penn State University (2009). I started my research in Bioinformatics since the very beginning of my PhD period and have been working on several great projects, focusing on computational modeling of the GATA-1-related Erythroid regulation. After that, I joined Dr. Eric Harvill’s lab to apply comparative genomics on the understanding of the pathogenesis of B. pertussis, the causative agent of whooping cough.