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Tutorial Details: Introduction to Homology Modeling

Date: Wednesday, June 9, 2004, 01:00 pm - 03:00 pm
Location: 402 Walter
Instructor(s): Assistant Professor Yuk Y Sham PhD, Center for Drug Design

HOMOLOGY is a module within a commercially available software package called INSIGHTII. It is used to help build the structure of a protein by comparing its amino acid sequence with other homologous reference proteins whose atomic structures are known.

When the sequence region of two proteins share a high level of sequence similarity, the conformations of these two regions are assumed to be conserved and the structure of the unknown protein is generated based on this reference protein structure.

This tutorial will cover basic fundamental theory to HOMOLOGY as well as the basic procedure to generate protein structures from sequences using HOMOLOGY.

Prerequisites: Basic Molecular Biology Concepts