University of Minnesota
University Relations

Minnesota Supercomputing Institute

Log out of MyMSI

Tutorial Details: Homology Modeling Basics - CANCELED

Date: Thursday, April 28, 2011, 01:00 pm - 03:00 pm
Location: 402 Walter
Instructor(s): Can Erol Ergenekan, MSI

Homology modeling, or comparative modeling, is a process used to produce an atomic model of a protein structure when an experimental model does not exist. This is done by using a protein with a known structure and a similar primary sequence to the protein of interest to build a model. This method can be very useful in certain cases, but is very reliant on the quality of the sequence alignment and the template structure chosen as a basis for the model.

This lecture will cover the basic theories and pitfalls of using homology modeling to generate protein models, as well as what MSI has to offer in terms of software packages that you can use to make comparative models of your proteins.

Level: Introductory
Prerequisites: Basic understanding of protein structure concepts