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Tutorial Details: Array-based Genotyping

Date: Tuesday, April 5, 2011, 01:00 pm - 03:00 pm
Location: 575 Walter
Instructor(s): Wayne Xu, MSI

Genotyping refers to the process of determining the genotype of an individual by sequence information. Different genotypes may be associated with specific phenotypes; therefore, genotyping can be used for genetic associated disease studies, drug-resistance association studies, high-yield gene mapping or plant strain selection.

There are various methods available for genotyping. Recently, high-performance genotyping methods such as bead-based genotyping and next-generation sequencing genotyping have emerged. Moreover, there are different platform technologies available for array-based genotyping such as Affymetrix GeneChip, Illumina beadsArray, and Sequenom MassARRAY. This tutorial will compare these platforms in technical design and in their application. We will also demonstrate the use of software such as Affymetrix Genotyping Console™ (GTC), Illumina GenomeStudio, and Sequenom TyperAnalyzer by using sample data.

This tutorial will also introduce the genotyping software hosted in MSI including Illumina GenomeStudio, Genotyping Console™ (GTC) Software, GeneMapper, Sequenom Typer, Matlab Bioinformatics toolbox for SNPs, dChip, SOAP, GeneSpring 11, and Bioconductor for SNP.

Level: Intermediate
Prerequisites: None