MSI has a new high-performance computing system named Koronis. It features an SGI Altix UV 1000, one of the largest global shared memory (GSM) systems available. Koronis offers unprecedented opportunities for NIH researchers to conduct memory-intensive calculations. At the same time, it poses great computational challenges from the system-memory complexity that - combined with the flexibility in the selection of the number of computing cores - can severely degrade the performance. This tutorial will help Koronis users improve application performance. We will show examples of programs that can take advantage of this computer. We will also describe tactics that can be used in the calculations within the CPUset regime to achieve optimal performance.