College of Science & Engineering
Twin Cities
This research group studies the role of the cell microenvironment in development of healthy and diseased tissues for applications in regenerative medicine and cancer therapeutics. In particular, they investigate mechanisms of tumor progression and metastasis, cellular quiescence and reawakening, growth kinetics and metabolism, and barrier function and disregulation in the brain and the intestine. Bioinformatics analysis of the transcriptome and proteome are critical in elucidating mechanisms underlying the phenomena studied. Given the large amount of data generated from these bioinformatics approaches necessitate the use of MSI resources for storage and analysis of bioinformatics data. Current projects include identifying transcriptome changes upon acquisition of chemoresistance and induction of dormancy in ovarian cancer cells as well as the effects of multiple rounds of activation on the transcriptome of natural killer cells.