Medical School
Twin Cities
Resting state functional connectivity (RSFC) 66 has obvious potential for clinical applications and understanding brain mechanisms. However, unlike structural imaging, which allows visualization of anatomic details of individual brains, RSFC has yet to be widely used clinically for patient-level evaluation, diagnosis, or prognosis. This may be explained by the fact that the BOLD signal has a very low signal-to-noise ratio. Hence, the very limited amount of data collected in conventional large-scale imaging studies (i.e.,~5-10 minutes) generates unreliable estimates of functional brain organization. High single-subject reliability with functional data is challenging but achievable. This group is intending to acquire PFM on treatment resistant depressed patients and use that anatomical and functional data to better target neuromodulation therapies.